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Rhoden EL, Morgentaler A. Risks of testosterone-replacement remedy and proposals for monitoring. Testosterone alternative in hypogonadal men with angina improves ischaemic threshold and high quality of life. Ajayi AAL, Mathur R, Halushka PV. Testosterone improve human platelet thromboxane A2 receptor density and aggregation responses.
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Moreover, a component of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity. However, testosterone in physiologic doses might even be useful in patients with angina , have greater ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood circulate in men with established coronary artery illness . Therefore, an interplay of endogenous components of the patient’s danger profile as well as the testosterone dosing may be problems with whether antagonistic events happen.
We report a case of an acute ST-segment elevation myocardial infarction in a patient with traditional cardiac threat factors utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person additionally had polycythemia, doubtless secondary to high-dose testosterone. The affected person underwent successful percutaneous intervention of the proper camspda coronary artery. Physicians and sufferers ought to pay consideration to the scientific penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996).
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